Background
MRC Technology (MRCT) is a technology transfer organisation that helps bridge the gap between basic medical research and commercial application. Our goal is to ensure that innovative life science research reaches its full potential. We were initially set up to identify, protect and commercialise IP arising from the UK’s Medical Research Council, but today we also translate early discoveries into partnered assets for universities, medical research charities, and pharmaceutical and biotechnology organisations around the world.

Our Centre for Therapeutics Discovery takes novel academic targets and generates lead stage small molecules and therapeutic antibodies for indications with unmet medical need. This activity is currently based in our laboratories in North London where we have more than 60 research scientists in biology and medicinal chemistry. In late 2015, this site will be relocating to a brand new facility within the Stevenage BioCatalyst site.

Placements
MRC Technology is looking for 3 placement students to work within our Centre for Therapeutics Discovery group during the 2015/16 academic year in our new laboratories in Stevenage.

The successful students will be expected to fully participate in our project work and, although they will be directly supervised by one of our experienced team members, will find they are working with a team in a range of areas in the drug discovery process.

The Biology Department is responsible for providing all of the Biology support for the small molecule drug discovery programs. This includes Assay Development and Screening, Compound Profiling and Cellular Pharmacology Group and BioTherapeutics.

Each student will be a member of a project team with clearly identified responsibilities. A student is likely to gain experience of the following activities:

  • Reagent generation
  • Assay design and optimisation
  • Assay miniaturisation and automation
  • High Throughput Screening
  • Hit compound confirmation studies
  • Target validation studies (siRNA, pharmacological validation)
  • Cell based assays for supporting hit to lead chemistry programs
  • Selectivity assays
  • Developing and running disease relevant assays
  • Hybridoma Generation
  • Molecular Biology
  • Protein Engineering
  • Antibody Optimisation and Chemistry

Regular verbal presentations of experimental results and conclusions will be given by the students to the project team and they will be expected to maintain high quality written lab notebook records of their research.

To assist their degree submission an area of research will be identified to support any written project requirements.

Additional Information
All positions will be paid around £16,000 per annum.

These roles will begin in September 2015 and run for approximately 50 weeks.

How to apply

To apply please email your CV and covering letter to: recruitment@tech.mrc.ac.uk or by post to Recruitment, MRC Technology, Lynton House, 7-12 Tavistock Square, London, WC1H 9LT (electronic applications preferred).

Closing date: Friday 10th October 2014

Central London
Competitive salary plus benefits

MRC Technology (MRCT) is a technology transfer organisation responsible for adding commercial value to cutting edge scientific discoveries through strategic patent protection, creative licensing of intellectual property (IP), partnered research or further scientific development and also runs one of the largest academic drug discovery groups in the UK. MRCT’s Centre for Therapeutic Discovery (CTD) has expertise in both small molecule and therapeutic antibody drug discovery and works to develop exciting new drugs for a broad range of unmet medical needs.

A vacancy has arisen for a Technology Transfer Administrator within the Intellectual Property and Licensing Division (IPL) of MRCT.  The post provides administrative support for MRCT’s work on the protection and commercial exploitation of MRC inventions and collaborations with industry as well as MRCT’s own drug discovery facility, the Centre for Therapeutics Discovery.

Reporting into one of the Senior Business Managers the main responsibility will be managing patent formalities for 3/4 Business Managers within IPL. This will include coordinating patent related administration to ensure procedural obligations are met, maintaining accurate electronic records of all patent related documents and correspondence to ensure business continuity, liaising with colleagues in IPL and other divisions in relation to monitoring agreement income and outgoing revenue and reporting on key data.

A wide range of administrative and organisational skills are required with particular emphasis on good oral and written communication skills, attention to detail, and experience of using databases. Knowledge of intellectual property, particularly the patenting process, would be an advantage.

In addition MRCT offers a defined contribution pension scheme, private health insurance, a flexible benefits scheme and 31 days paid holiday per year.

How to apply

To apply please email your CV and covering letter to: recruitment@tech.mrc.ac.uk  or by post to Recruitment, MRC Technology, Lynton House, 7-12 Tavistock Square, London, WC1H 9LT (electronic applications preferred).

Closing date: 19th September 2014

Edinburgh

There is an exciting opportunity for a scientist, with a post graduate degree in life sciences or equivalent experience, to join a team delivering commercially-focussed diagnostic development projects. You will work alongside a small committed development team in Edinburgh and work collaboratively within the organisation and with 3rd parties.

The nature of work would involve designing and developing diagnostic assays in line with agreed project timelines and could include –

- Working up protocols/methodologies for delivery in a clinical environment.

- Evaluating prototypes on clinical samples.

- Assessing new or novel diagnostic technologies.

- Executing validation plans for diagnostic assays and equipment.

- Evaluating and analysing data.

- Optimising extraction methodologies.

- Working within a Quality compliant framework to ensure that the relevant documentation and practices are in place to deliver requirements.

Due to the nature of the work, the individual could expect to work on projects at different stages of the project lifecycle.

Skills/Experience

- Demonstrable experience in assay design & development, particularly in the areas of molecular biology or immunohistochemistry.

- Experience in the following technologies – qPCR, IHC, in situ PCR, sequencing (NGS or Sanger), nucleic acid extraction technologies, automated systems, ELISA, histology methods (i.e. tissue processing, sectioning, mounting, staining).

- Previous experience working in the areas of infectious diseases or oncology would be advantageous.

- Experience working in a clinical or diagnostic environment would be advantageous, or having worked under a quality management system such as ISO15189 or ISO13485.

- Project management experience, such as PRINCE2 would be desirable.

MRC Technology offers a competitive salary, a defined contribution pension scheme, private health insurance and other flexible benefits along with 31 days paid holiday per year.

How to apply

To apply please email your CV and covering letter, quoting the reference CLT-S to: recruitment@tech.mrc.ac.uk or by post to Recruitment, MRC Technology, Lynton House, 7-12 Tavistock Square, London, WC1H 9LT (electronic applications preferred).

Closing Date: 26 September 2014