MRC Technology (MRCT) is an independent life science medical research charity committed to drastically improving positive patient outcomes everywhere. As a champion for human health, MRC Technology partners with academic, biotechnology, pharmaceutical and charity organisations to move promising medical research forward into viable and accessible patient treatments.

Our Centre for Therapeutics Discovery (CTD), recently relocated to the Stevenage Bioscience Catalyst research campus, operates at the interface between academic research and the drug discovery industry. As one of the largest and most successful academic drug discovery centres in Europe, we take novel academic targets and generate lead stage small molecules and therapeutic antibodies for indications with unmet medical need.

The BioTherapeutics Department has a wealth of experience in antibody design and deliver humanised antibodies using a range of methods. Importantly they also optimise the potency and the biophysical characteristics of the antibodies to ensure what they deliver have the best chance of being drugs. They work closely with the Biology Department to gain insights into the performance of our antibodies in relevant biological tests. In addition, they work with the chemistry team on novel technologies such as antibody-drug conjugation.

We are seeking two highly motivated scientists, who will generate antibody libraries from different sources and carry out phage display selections campaigns. Previous experience in antibody phage display is a MUST.

Your role will be primarily laboratory based, with opportunities to grow and learn in antibody phage display and antibody engineering.

Skills and previous experience

• Experience in broad range of molecular biology cloning methods [required]
• Experience working with phage display or another display technology [required]
• Experience working with full antibodies, or antibody fragments [required]
• Experience in next-generation sequencing [preferable]
• MSc with 3-4 years industrial experience, or PhD with 1-2 years industrial experience, preferably in antibody biotherapeutics [required]
• Ability to critically assess and analyse data [required]
• Excellent communication and team working skills [required]
• Versatile and willing to be exposed to a number of different projects [required]

Both positions would suit Scientists who enjoy working as key members of cross functional project teams and have excellent communication and team working skills. Successful candidates will enjoy thinking “outside the box” and presenting results and ideas in a fast paced environment.

Your salary will be determined by qualifications and experience. In addition MRCT offers a defined contribution pension scheme, private health insurance, a flexible benefits scheme and 31 days paid holiday per year.

To apply please email your CV and covering letter explaining why you want to work for MRC Technology to: recruitment@tech.mrc.ac.uk or by post to Recruitment, MRC Technology, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX (electronic applications preferred).

Closing date: 23 October 2016

How to apply

Email: recruitment@tech.mrc.ac.uk

MRC Technology (MRCT) is an independent life science medical research charity committed to drastically improving positive patient outcomes everywhere. As a champion for human health, MRC Technology partners with academic, biotechnology, pharmaceutical and charity organisations to move promising medical research forward into viable and accessible patient treatments.

Our Centre for Therapeutics Discovery (CTD), recently relocated to the Stevenage Bioscience Catalyst research campus, operates at the interface between academic research and the drug discovery industry. As one of the largest and most successful academic drug discovery centres in Europe, we take novel academic targets and generate lead stage small molecules and therapeutic antibodies for indications with unmet medical need.

The BioTherapeutics Department has a wealth of experience in antibody design and deliver humanised antibodies using a range of methods. Importantly they also optimise the potency and the biophysical characteristics of the antibodies to ensure what they deliver have the best chance of being drugs. They work closely with the Biology Department to gain insights into the performance of our antibodies in relevant biological tests. In addition, they work with the chemistry team on novel technologies such as antibody-drug conjugation.

We are seeking a highly motivated individual with experience of working on Antibody based drug discovery projects. With an attention to detail, you will be expected to show initiative and work collaboratively to drive successful antibody based drug discovery projects in a number of therapeutic areas.

Your role will involve working on multiple projects, and will suit a highly organized individual with excellent skills in time management. You will be part of a team developing and optimising drug like properties of antibodies across a number of antibody research programmes.

You will have in-depth research experience of Antibody engineering and characterisation with biochemical and biophysical methods.

The successful candidate must have a proven track record of molecular biology, cell biology and protein biochemistry skills. These will include general molecular biology skills such as cloning, PCR, DNA transfection, and protein biochemistry such as ELISA, protein/antibody purification, SDS PAGE. A strong knowledge of protein structure and biophysical analysis will be an asset.

Previous work experience of antibody drug discovery within the pharmaceutical or Biotechnology industry would be advantageous.

The candidate should ideally be qualified to PhD or a BSc/MSc with suitable work experience.

Your salary will be determined by qualifications and experience. In addition MRCT offers a defined contribution pension scheme, private health insurance, a flexible benefits scheme and 31 days paid holiday per year.

To apply please email your CV and covering letter explaining why you want to work for MRC Technology to: recruitment@tech.mrc.ac.uk or by post to Recruitment, MRC Technology, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX (electronic applications preferred).

Closing date: 23 October 2016

How to apply

Email: recruitment@tech.mrc.ac.uk

Background

MRC Technology (MRCT) is an independent life science medical research charity committed to drastically improving positive patient outcomes everywhere. As a champion for human health, MRC Technology partners with academic, biotechnology, pharmaceutical and charity organisations to move promising medical research forward into viable and accessible patient treatments.
MRC Technology’s Centre for Therapeutics Discovery (CTD) operates at the interface between academic research and the drug discovery industry. As one of the largest and most successful academic drug discovery centres in Europe, we take novel academic targets and generate lead stage small molecules and therapeutic antibodies for indications with unmet medical need. As part of an exciting phase in our development we have recently relocated to state of the art facilities on the Stevenage Bioscience Catalyst site.

Placements

MRC Technology is looking for 6 placement students to work within our Centre for Therapeutics Discovery group during the 2017/18 academic year.

The successful students will be expected to fully participate in our project work and, although they will be directly supervised by one of our experienced team members, will find they are working with a team in a range of areas in the drug discovery process.

Placements are available in our Biology Group and our BioTherapeutics Group.

A student is likely to gain experience of the following activities:

Biology:

• Reagent generation
• Assay design and optimisation
• Assay miniaturisation and automation
• High Throughput Screening
• Hit compound confirmation studies
• Target validation studies (siRNA, pharmacological validation)
• Cell based assays for supporting small molecule and/or antibody programs
• Selectivity assays
• Developing and running disease relevant assays

Biotherapeutics:

• Hybridoma Generation
• Molecular Biology
• Protein Engineering
• Antibody Optimisation and Chemistry

Regular verbal presentations of experimental results and conclusions will be given by the students to the project team and they will be expected to maintain high quality written lab notebook records of their research.

To assist their degree submission an area of research will be identified to support any written project requirements.

Additional Information

All positions will receive a salary of £18,000 per annum.
These roles will begin in September 2017 and run for approximately 50 weeks.

How to Apply

To apply please email your CV and covering letter to: recruitment@tech.mrc.ac.uk or by post to Recruitment, MRC Technology, Accelerator Building, Open Innovation Campus, Stevenage, SG1 2FX (electronic applications preferred). Please indicate in your covering letter if you have preference for working in the Biology Group or the Biotherapeutics Group.

Further details about MRC Technology can be found on www.mrctechnology.org

Closing date: Sunday 16th October 2016

How to apply

Email: recruitment@tech.mrc.ac.uk

How to apply

Email: recruitment@tech.mrc.ac.uk