MRC Technology (MRCT) is a technology transfer organisation that helps bridge the gap between basic medical research and commercial application. Our goal is to ensure that innovative life science research reaches its full potential. We were initially set up to identify, protect and commercialise IP arising from the UK’s Medical Research Council, but today we also translate early discoveries into partnered assets for universities, medical research charities, and pharmaceutical and biotechnology organisations around the world.
Our Centre for Therapeutics Discovery takes novel academic targets and generates lead stage small molecules and therapeutic antibodies for indications with unmet medical need. This activity is currently based in our laboratories in North London where we have more than 60 research scientists in biology and medicinal chemistry. In late 2015, this site will be relocating to a brand new facility within the Stevenage BioCatalyst site.
MRC Technology is looking for 3 placement students to work within our Centre for Therapeutics Discovery group during the 2015/16 academic year in our new laboratories in Stevenage.
The successful students will be expected to fully participate in our project work and, although they will be directly supervised by one of our experienced team members, will find they are working with a team in a range of areas in the drug discovery process.
The Biology Department is responsible for providing all of the Biology support for the small molecule drug discovery programs. This includes Assay Development and Screening, Compound Profiling and Cellular Pharmacology Group and BioTherapeutics.
Each student will be a member of a project team with clearly identified responsibilities. A student is likely to gain experience of the following activities:
- Reagent generation
- Assay design and optimisation
- Assay miniaturisation and automation
- High Throughput Screening
- Hit compound confirmation studies
- Target validation studies (siRNA, pharmacological validation)
- Cell based assays for supporting hit to lead chemistry programs
- Selectivity assays
- Developing and running disease relevant assays
- Hybridoma Generation
- Molecular Biology
- Protein Engineering
- Antibody Optimisation and Chemistry
Regular verbal presentations of experimental results and conclusions will be given by the students to the project team and they will be expected to maintain high quality written lab notebook records of their research.
To assist their degree submission an area of research will be identified to support any written project requirements.
All positions will be paid around £16,000 per annum.
These roles will begin in September 2015 and run for approximately 50 weeks.