Central London
Competitive Salary, with opportunity for progression

Closing date: 11th February 2015.
Interviews likely to be in the week beginning 16th February.

MRC Technology (MRCT) is a technology transfer organisation responsible for adding commercial value to cutting edge scientific discoveries through strategic patent protection, creative licensing of intellectual property (IP), partnered research or further scientific development and also runs one of the largest academic R&D groups in the UK undertaking drug discovery and medical diagnostic development activities. MRCT’s Centre for Therapeutic Discovery (CTD) and Centre for Diagnostic Development (CDD) respectively work to develop exciting new drugs and diagnostic assays for a broad range of unmet medical needs.  MRCT also provides technology transfer-related services to a range of organisations, including the Medical Research Council (MRC).

MRCT is seeking an experienced Licensing and Agreements Officer to join its Intellectual Property and Licensing division.  Your main responsibilities will be to review, draft and negotiate a range of agreements related to research activities undertaken by, and intellectual property arising in, MRC Units and Institutes. You may also be asked to review, draft and negotiate agreements related to projects undertaken by MRCT-CTD and MRCT-CDD as well as agreements arising from the technology transfer services MRCT provides to its other clients. Therefore, flexibility is an essential requirement.

Ideally you should have at least 2 years’ experience of drafting and negotiating a diverse range of agreements, including IP licences, research collaboration, material transfer, confidentiality and other technology transfer-related agreements. Education to degree level and qualifications in a biomedical-related and/or a legal discipline are desirable but not essential.

The job requires detailed and up to date understanding of complex issues surrounding research and commercialisation of IP, including commercial licensing/application of IP arising from research, good communication skills, including precise use of language, an ability to work under pressure to meet set deadlines and an ability to establish and maintain effective working relationships with a wide variety of individuals.  A good understanding of issues relating to liability, warranties and indemnification would be especially desirable.

Your salary will be determined by qualifications and experience.  In addition MRCT offers a defined contribution pension scheme, private health insurance, a flexible benefits scheme and 31 days paid holiday per year.

How to apply

To apply please email your CV and covering letter to: recruitment@tech.mrc.ac.uk or by post to Recruitment, MRC Technology, Lynton House, 7-12 Tavistock Square, London, WC1H 9LT (electronic applications preferred).

MRC Technology’s Centre for Therapeutics Discovery (CTD) operates at the interface between academic research and the Drug Discovery industry. As one of the largest and most successful academic drug discovery centres in Europe, we take novel academic targets and generate lead stage small molecules and therapeutic antibodies for indications with unmet medical need. We have a proven track record in partnering our assets with pharma and biotech companies; 4 of our projects have led to approved drugs (Tysabri®, Actemera®, Entyvio®, Keytruda®) and we have a strong pipeline in development. We have a number of drug discovery alliances with pharma (AstraZeneca, Daiiachi Sankyo) and are a key player in the Dementia Consortium alongside Eisai, Lilly and Alzheimer’s Research UK. The next exciting phase of our development includes relocating our laboratory from Mill Hill, North London to “state of the art” facilities on the Stevenage BioCatalyst site within the next 12 months.

The Biology Group supports both small molecule and antibody projects, working closely with our Chemistry and Biotherapeutics Groups. Within the Biology Group we are looking to expand our Assay Development and Screening Group and have 2 exciting opportunities for talented, motivated individual who want to contribute to early drug discovery. Working as key members of cross functional project teams these openings provide excellent opportunities to work on cutting edge novel research with translational potential.

(ADSG1) Screening Scientist- Automation Specialist
You will work as part of a team of biologists and collaborating external scientists to establish assays suitable for HTS, SAR support and hit profiling.  In addition you will be responsible for maintaining automation equipment and provide training and assistance to others in the use of robotics.

You will have a PhD qualification or be a graduate possessing considerable relevant laboratory experience of assay development, automating assays, running screen campaigns and hit profiling, be highly experienced in writing automation protocols and trouble-shooting automation issues.  In addition you will have a broad range of technical skills which can be applied to assay development and screening of small molecules for drug discovery. You will have the ability to apply or adapt appropriate technologies to a range of novel targets –both biochemical and cell based

Main responsibilities:

  • Independently designs and conducts experiments for the development of assays suitable for HTS, hit characterisation, SAR support or optimisation of biological therapeutic.
  • Writes standard operating procedures for optimised assays, which can be followed by other team members and contributes to project reports.
  • Independently optimizes and adapts assays to robotic liquid handling equipment.
  • Co-ordinates and runs HTS and regular compound submissions for projects in SAR support using automated methods.
  • Provides training and support to others for Biomek Fx.

Key skills:

  • Biomek FX or equivalent robotics programming skills
  • ABASE or equivalent data handling software
  • Enzyme or cellular fluorescence/absorbance based assays.
  • Assay optimisation
  • Broad knowledge cellular pharmacology, protein biochemistry and skilled in searching the scientific literature.
  • Competent in Microsoft Office packages and more specialist scientific software eg ABASE
  • Good written and oral communication.

 

(ADSG2) Scientist– Enzymology Specialist
You will work as part of a team of biologists and collaborating external scientists to establish assays suitable for HTS, SAR support and mechanism of action studies.

You will have a PhD qualification or be a graduate possessing considerable relevant laboratory experience in molecular biology, protein expression and enzymology.  You will have experience of characterising small molecule inhibition and knowledge of early phase drug discovery.  Experience of automating assays would be desirable, but is not essential.

Main responsibilities:

  • Independently designs and conducts experiments for the development of assays suitable for HTS, hit characterisation, SAR support or optimisation of biological therapeutic.
  • Independently optimizes and adapts assays to robotic liquid handling equipment.
  • Co-ordinates and runs HTS or regular compound submissions for projects in SAR support using automated methods.
  • Writes standard operating procedures for optimised assays, which can be followed by other team members and contributes to project reports .

Key skills:

  • Experienced in biochemical assay design for screening and hit characterisation
  • Broad knowledge of protein expression and characterisation, molecular biology and enzymology and skilled in searching the relevant scientific literature.
  • Competent in Microsoft Office packages and more specialist scientific software eg Graphpad Prism
  • Practices safe laboratory working practice (including working with ionising radiation) according to local rules.
  • Good written and oral communication

Your salary will be determined by qualifications and experience. In addition MRCT offers a Defined Contribution pension scheme, Private Health Insurance, a flexible benefits scheme and 31 days paid holiday per year.

MRC Technology’ (www.mrctechnology.org) is an independent life science medical research charity, offering professional services to organisations within the academic, charity, biotechnology and pharmaceutical sectors globally. Services include IP management and research and development for diagnostics, small molecules and therapeutic antibodies. We bridge the gap between basic medical research and commercialisation, helping early discoveries progress to clinical application.

Closing date: Friday 13th February 2015

How to apply

To apply please email your CV and covering letter explaining why you want to work for MRC Technology’s CTD to: recruitment@tech.mrc.ac.uk or by post to Recruitment, MRC Technology, Lynton House, 7-12 Tavistock Square, London, WC1H 9LT (electronic applications preferred).

Please state which role you are applying for by adding ADSG1 or ADSG2 in the header.